Order of the Mutant 5e

Blood hunters who use mutagenic formulas to temporarily enhance their bodies, gaining powerful buffs with corresponding side effects.

Part of the Blood Hunter class

At a Glance

Parent Class

Blood Hunter

Subclass Level

3rd level

Source

Critical Role

Focus

Mutagenic formulas granting temporary physical enhancements with side effects

Feature	Level	Description
Formulas	3rd	Learn 3 mutagen formulas (more at higher levels). Create mutagens during short rest.
Mutagencraft	3rd	As bonus action, consume mutagen for benefit and drawback lasting until short rest. Can have one active (more later).
Strange Metabolism	7th	Immunity to poison damage and poisoned condition. Can end mutagen early as bonus action.
Brand of Axiom	11th	Branded creature can't move more than 30ft from you, teleportation fails, and can't become invisible/hidden.
Blood Curse of Corrosion	15th	New blood curse that deals acid damage and reduces AC.
Exalted Mutation	18th	One mutagen's drawback doesn't affect you.

Common Mistake

Ignoring mutagen drawbacks - they're significant debuffs

Common Mistake

Not preparing the right mutagens for expected challenges

Common Mistake

Forgetting you can end mutagens early at 7th level

DM Tip

The Witcher inspiration is strong - lean into the alchemist fantasy

DM Tip

Mutagen choices create interesting tactical decisions

DM Tip

The drawbacks are real - exploit them if targeting a Mutant blood hunter